Process for the preparation of microballs and microballs thus ob

Details Process for the preparation of microballs and microballs thus ob Process for the preparation of microballs and microballs thus ob

1994-05-16

1996-10-29

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, A61K 914

Patent

active

055694675

ABSTRACT:
A method of making microballs is disclosed. An active ingredient, a biocompatible polymer and a supporting phase, such as silicone oil, are stirred at a temperature above the Tg of the polymer and below the temperature at which any of the ingredients vaporizes or degrades. Stirring is continued until microballs of the desired diameter are formed, whereafter the mixture is cooled and the microballs are separated from the supporting phase. The microballs are substantially spherical, substantially smooth on their external surface and have substantially no active ingredient on their external surface.

REFERENCES:
patent: 4010125 (1977-03-01), Schally et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4844910 (1989-07-01), Leslie et al.
patent: 4867985 (1989-09-01), Heafield et al.
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5213812 (1993-05-01), Ruiz
patent: 5225205 (1993-07-01), Orsolini
E. Mathiowitz et al., "Polyanhydride Microspheres as Drug Carriers: Hot-Melt Microencapsulation", Journal of Controlled Release, 5;1 (1987) 13-22.

Affiliated with

Also associated with

Rating

Process for the preparation of microballs and microballs thus ob does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of microballs and microballs thus ob, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of microballs and microballs thus ob will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1784365