Process for the preparation of methyl esters of arylpropionic ac

Details Process for the preparation of methyl esters of arylpropionic ac Process for the preparation of methyl esters of arylpropionic ac

1982-08-05

1984-03-27

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 20, 560 21, 560 51, 560100, 560102, 560105, 562466, 562406, 260465C, C07C 6976

Patent

active

044396180

ABSTRACT:
Optically active methyl esters of arylpropionic acids are prepared by reaction of the corresponding vinylaromatic compounds with carbon monoxide and methyl alcohol in the presence of a palladium catalyst system consisting of a palladium compound associated with optically active diphenyl-neomenthylphosphine and with trifluoroacetic acid, at substantially atmospheric pressure and at a temperature comprised between 20.degree. and 80.degree. C. There is dealt with particular regioselective and enantioselective catalysis conditions.
The products obtained consist of esters of arylpropionic acids or of the corresponding acids obtainable from them, and are useful intermediates in the synthesis of organic compounds, particularly of pharmaceutical products.

REFERENCES:
patent: 3530168 (1970-09-01), Biale et al.
patent: 3839378 (1974-10-01), Yamaguchi et al.

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