Process for the preparation of metabolites of Ginseng saponins

Details Process for the preparation of metabolites of Ginseng saponins Process for the preparation of metabolites of Ginseng saponins

1997-12-01

1999-07-20

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435 712, 435 74, 4352521, 4241951, 514 26, 536 5, C12N 120, C12P 3320, A01N 6500

Patent

active

059255374

ABSTRACT:
According to this invention, Prevotella sp. S-1 strain (Bacteroidaceae family, KFCC-10923) is cultured in a medium supplemented with Panax ginseng saponin so as to collect the metabolites of saponin generated and accumulated in the medium, thus ensuring their selective production with high efficiency.
This invention related to a process for the preparation of the metabolites of protopanaxadiol saponin, wherein Prevotella sp. S-1 strain (Bacteroidaceae family, KFCC-10923), is cultured at a medium supplemented with Panax ginseng saponin and then, the metabolites of protopanaxadiol saponin contained in the medium--20-O-.beta.-D-glucopyranosyl-20(s)-protopanaxadiol, )-protopanaxadiol --are generated and accumulated for collecting them thereof.

REFERENCES:
Chemical Pharm. Bull., Yostoea et al, Soil Bacteria Hydrolysis Leading to Genuine Aglycone V . . . , pp. 2418-2421, 1972.
Yakugaku Zasshi, Kohda et al, Enzymatic Hydrolysis of Saponins and Their Related Glycosides, pp. 246-249, 1975.
Medicinal Ginseng, "Ginsenoside Rb.sub.2 ", pp. 246-278, 1989.
Journal of Traditional Medicinen, Kanaoka et al, "Metabolism of Ginsing Saponins . . . ", pp. 241-245, 1994.
Bergey's Manual of Systemic Bacteriology, pp. 616-617, 1984.
Int'l. Journal of Systematic Bacteriol, Shah et al, Prevotella, a New Genus To Include Bacteroides . . . , pp. 205-208, 1990.
Chemical Computer Abstract CA127:275173 Hasegawa et al "Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins" Planta Med. (1997) 65(5) pp. 436-440.

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