Process for the preparation of medication in the form of pearls

Details Process for the preparation of medication in the form of pearls Process for the preparation of medication in the form of pearls

1992-07-21

1995-01-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424458, 424473, 424490, 424494, 424497, A61K 948

Patent

active

053805321

ABSTRACT:
Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point.
The said active substance is mixed in molten form with a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

REFERENCES:
patent: 4035116 (1977-07-01), O'Brien et al.
patent: 4283325 (1981-08-01), Berthet
patent: 4313745 (1982-02-01), Kendall
patent: 4389356 (1983-06-01), Higgins
patent: 4483867 (1984-11-01), Svahn
patent: 4525198 (1985-06-01), Van Hijfte et al.
patent: 4548818 (1985-10-01), Kjellin
patent: 4627943 (1986-12-01), Seidler
patent: 4913865 (1990-04-01), Toyotama

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