Process for the preparation of lyophilized, adsorbed polyvalent

Details Process for the preparation of lyophilized, adsorbed polyvalent Process for the preparation of lyophilized, adsorbed polyvalent

1984-02-22

1986-03-25

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424101, A61K 3902

Patent

active

045782709

ABSTRACT:
The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an insoluble carrier concentrated in the same way as the antigens, then the pH of the mixture is adjusted to a value of 5 to 6 and lyophilized together with a protective material commonly used in lyophilizing processes. Before administration the lyophilized vaccine is diluted to the concentration required by a physiological saline buffered to a pH value of 6.8 to 7 by a phosphate solution.

REFERENCES:
patent: 2085391 (1937-06-01), Reichel
patent: 3595753 (1971-07-01), Stejskal et al.
patent: 3599150 (1971-08-01), Feinberg et al.
patent: 3743720 (1973-07-01), Fosker et al.
patent: 3983229 (1976-09-01), Relyveld
patent: 4007265 (1977-02-01), Helting
patent: 4157389 (1979-06-01), Homma et al.
patent: 4273762 (1981-06-01), McAleer et al.

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