Process for the preparation of leukotriene anatgonists

Details Process for the preparation of leukotriene anatgonists Process for the preparation of leukotriene anatgonists

1995-05-12

1997-03-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21518

Patent

active

056146329

ABSTRACT:
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof ##STR1## wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercaptomethyl)cyclopropaneacetic acid with a compound of formula (II) ##STR2## wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).

REFERENCES:
patent: 5270234 (1993-12-01), Zamboni et al.
patent: 5428033 (1995-06-01), Belley
King, et al, J. Org. Chem. 1993, 58:3731-3735.

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