Process for the preparation of lactones

Details Process for the preparation of lactones Process for the preparation of lactones

1976-09-20

1978-08-08

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D31300

Patent

active

041056736

ABSTRACT:
An improved process for producing a large ring lactone which comprises subjecting a hydroxy acid to intramolecular condensation by the use of a 1-substituted-2-halopyridinium salt or a 1-substituted-2-haloquinolinium salt as a condensing agent in the presence of an acid captor in an anhydrous organic solvent. According to this process, a variety of lactones, even complex lactones such as macrolides can be obtained in good yields.

REFERENCES:
corey et al., J. Amer. Chem. Soc., 96, p. 5614, 1974.
Osamu Okuda, Perfume Chemical Index, pp. 1209-1216, 1968.
Poucher et al., Perfumes, Cosmetics and Soaps, vol. 1, pp. 29 and 163-164, published in 1974.
Apsimon, "The Total Syn. of Natural Products", vol. 1, pp. 426-433, Wiley, 1973.
J.A.C.S., vol. 78, 6390-6393, 1956.
Hel. Chi. Acta., vol. 46, pp. 1235-1243, 1963.

Affiliated with

Also associated with

Rating

Process for the preparation of lactones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of lactones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of lactones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-918784