Process for the preparation of lactam derivatives

Details Process for the preparation of lactam derivatives Process for the preparation of lactam derivatives

1991-05-22

1993-03-23

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 87, 546220, C07D47104

Patent

active

051965348

ABSTRACT:
The invention relates to a process for the preparation of a compound of formula (I) ##STR1## wherein R represent a hydrogen atom or a methyl or ethyl group, which comprises cyclising a compound of formul (IV) ##STR2## Where R represents a hydrogen atom, the compound of formula (IV) may optionally be alkylated to produce a compound in whcich R is methyl or ethyl.
The compound of formula (I) is useful as an intermediate in the preparation of 2,3,4,5-tetrahydro-2-[(imidazol-4(or 5)-yl)methyl]-1H-pyrido[4,3-b]indol-1-ones having 5-HT.sub.3 antagonist activity.

REFERENCES:
patent: 3316271 (1967-04-01), Cohen et al.
patent: 4985422 (1991-01-01), North et al.
Mar., Advanced Organic Chemistry, Second Edition, p. 326 McGraw-Hill pub. 1979.

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