Process for the preparation of L-homoalanin-4-yl(methyl)-phosphi

Details Process for the preparation of L-homoalanin-4-yl(methyl)-phosphi Process for the preparation of L-homoalanin-4-yl(methyl)-phosphi

1986-12-01

1988-10-11

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558174, C07F 932

Patent

active

047772794

ABSTRACT:
Process for the preparation of L-homoalanin-4-yl(methyl)-phosphinic acid (esters) of the formula I ##STR1## (R, R.sub.1 =H, alkyl) or salts thereof by reacting an R-3-isopropyl-2,5-dialkoxy-3,6-dihydropyrazine of the formula II with a .beta.-halogenoethyl(methyl)phosphinic acid ester of the formula IV ##STR2## (R', R.sub.1 '=alkyl) to give compounds of the formula V ##STR3## and then subjecting the latter to hydrolytic cleavage.

REFERENCES:
patent: 4599207 (1986-07-01), Lachheim et al.

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