Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1985-10-28
1989-11-14
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435115, 435108, 435227, 435228, 4352533, 435280, C12P 1304, C12P 1308, C12P 1322, C12N 978
Patent
active
048807370
ABSTRACT:
The invention relates to a process for preparation of L-.alpha.-amino acid and D-.alpha.-amino acid amide from DL-.alpha.-amino-acid amide by contacting the DL-.alpha.-amino acid amide in an aqueous solution with an .alpha.-amino acid amidase containing preparation obtained from a culture of Pseudomonas putida in the presence of traces of bivalent metal ions as activator, characterized in that the aqueous solution also contains a potassium salt selected from the group consisting of potassium sulphate and potassium chloride.
The invention further relates to a process for the preparation of L-.alpha.-amino acid and D-.alpha.- amino acid amide starting from the corresponding aldehyde, potassium cyanide and ammoniumsulphate, subsequent treatment with a ketone and potassiumhydroxide and finally subjecting to enzymatic hydrolysis with a preparation obtained from Pseudomonas putida.
REFERENCES:
patent: 3971700 (1976-07-01), Boesten
patent: 4080259 (1978-03-01), Boesten et al.
Neilands et al., "Isolation Methods", in Outlines of Enzyme Chemistry, pp. 21-33, John Wiley and Sons, Inc., 1955.
Greenstein et al., "Synthesis of .gamma.-Amino Acids" in Chemistry of the Amino Acids pp. 697-714, John Wiley and Sons, Inc., 1961.
"Commercial Applications of Immobilized Microorganism Cells." SRI Report No. 139, (1981), pp. 181-182.
Fong, Wing Sien., "Enzyme Technology." SRI International, Process Economics Program Report No. 139 (Jan. 1981), Complete Text, pp. 1-255, (including Table of Contents and 4 Sheets of Drawings).
Boesten Wilhelmus H. J.
Kerkhoffs Pieter L.
Knox Gail
Stamicarbon B.V.
Warren Charles F.
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