Process for the preparation of isothiocyanates

Details Process for the preparation of isothiocyanates Process for the preparation of isothiocyanates

1989-12-28

1991-03-05

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Isothiocyanate esters

C07C33100

Patent

active

049979671

ABSTRACT:
There is disclosed a process for the preparation of isothiocyanates of formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other C.sub.1 -C.sub.6 alkyl and R.sub.3, R.sub.4 and R.sub.5 are each independently of the other hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, trifluoromethyl or nitro, which process comprises an amine of formula ##STR2## with ammonium thiocyanate or an alkali metal thiocyanate, in the presence of acid and an inert solvent, to the thiourea of formula ##STR3## and cleaving said thiourea by heating. The essential feature of this process consists in carrying out the reaction of the amine of the above formula with ammonium thiocyanate or an alkali metal thiocyanate in the presence of 0.5-5% by weight of water, based on the total weight of the reaction mixture.
The isothiocyanates of the above formula are intermediates for the synthesis of pesticidal compounds.

REFERENCES:
Liquid-Liquid Equilibrium Data Collection, Sorensen, et al. (1979), Schon & Wetzel GmbH, pp. 482-487.

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