Process for the preparation of isosorbide-5-nitrate

Details Process for the preparation of isosorbide-5-nitrate Process for the preparation of isosorbide-5-nitrate

1982-04-23

1984-02-14

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49304

Patent

active

044318308

ABSTRACT:
In a process for preparing isosorbide-5-nitrate, isosorbide is reacted with an aliphatic carboxylic acid, with the formation of an acylation mixture. The acylation mixture is then nitrated, and the resulting nitration mixture is hydrolyzed and/or transesterified in order to split off acyl groups. The product is used in treatment of angina pectoris.

REFERENCES:
patent: 4371703 (1983-02-01), Stoss

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