Process for the preparation of isosorbide 2-nitrate

Details Process for the preparation of isosorbide 2-nitrate Process for the preparation of isosorbide 2-nitrate

1982-05-24

1983-11-22

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49304

Patent

active

044170653

ABSTRACT:
A process for the preparation of isosorbide-2-nitrate of the formula ##STR1## comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.

REFERENCES:
patent: 4065488 (1977-12-01), Chou et al.
patent: 4371703 (1983-02-01), Stoss

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