Process for the preparation of irbesartan

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S301100

Reexamination Certificate

active

08080670

ABSTRACT:
The present invention relates to a process for the preparation of 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]-1,3-diazaspiro[4,4]non-1-en-4-one by reaction of the corresponding nitrile with sodium azide and piperazine or its acid salt.

REFERENCES:
patent: 5270317 (1993-12-01), Bernhart et al.
patent: 5629331 (1997-05-01), Caron et al.
patent: 1918288 (2008-05-01), None
patent: 2005051943 (2005-06-01), None
patent: 2005/113518 (2005-12-01), None
patent: 2005113518 (2005-12-01), None
patent: 2007013101 (2007-02-01), None
patent: 2008010779 (2008-09-01), None
P.R. Bernstein and E.P. Vacek, Improved Conditions for the Formation of Tetrazoles, Medicinal Chemistry Department, Synthesis, 1987, 1133-1134.

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