Process for the preparation of iodophor compounds and methods fo

Details Process for the preparation of iodophor compounds and methods fo Process for the preparation of iodophor compounds and methods fo

1977-05-16

1978-09-12

Turner, V. D.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

252106, 424 80, A61K 3318

Patent

active

041138570

ABSTRACT:
An improved process for preparing iodophor preparations which comprises adding an ion selected from the group consisting of iodate, bromate, chlorite, chromate, hypochlorite, permanganate and persulfate ions and hydrogen peroxide to the iodine carrier selected from the group consisting of povidone, cationic, anionic and nonionic detergent compounds and an iodide salt, to result in a substantially pure iodophor compound which is virtually free of autodegraded iodide ion contamination and unreacted elemental iodine, said iodophor compounds exhibiting an enhanced stability. The process is also applicable to eliminate the presence of elemental iodine contaminants, iodide contamination and loss of titratable iodine during the process preparing pharmaceutical dosage forms containing iodophor active ingredients to enhance the stability and potency of the respective product.

REFERENCES:
patent: 3028300 (1962-04-01), Cantor et al.
patent: 3039916 (1962-06-01), Neracher et al.
patent: 3644650 (1972-02-01), Sabatelli et al.
Chemical Abstracts, vol. 59, (1963), p. 1266e.

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