Process for the preparation of intermediates useful in the prepa

Details Process for the preparation of intermediates useful in the prepa Process for the preparation of intermediates useful in the prepa

1995-05-26

1996-07-16

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 62, 544151, 544322, 544376, 546196, 5483114, 548525, 558 83, 558411, 549345, 549399, 549404, C07D27918, C07D31174

Patent

active

055368336

ABSTRACT:
A process for preparing compounds of the formula ##STR1## where a, b, c, R.sub.1, R.sub.2, and R.sub.3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3## where X is chlorine; bromine; --OC(O)--R.sub.5, where R.sub.5 is alkyl, aryl or substituted aryl; or --OCO.sub.2 R.sub.6, where R.sub.6 is alkyl or ##STR4## in the presence of a catalytic amount of a cuprous or cupric salt. The compounds of formula I are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.

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