Process for the preparation of intermediates useful in the prepa

Details Process for the preparation of intermediates useful in the prepa Process for the preparation of intermediates useful in the prepa

1993-10-01

1995-10-31

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558 83, 558411, 568442, 568630, 568631, 560 55, 562471, 564 52, 564 53, 564218, C07F 906

Patent

active

054630592

ABSTRACT:
A process for preparing compounds of the formula ##STR1## where a, b, c, R.sub.1, R.sub.2, and R.sub.3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3## where X is chlorine; bromine; --OC(O)--R.sub.5, where R.sub.5 is alkyl, aryl or substituted aryl; or --OCO.sub.2 R.sub.6, where R.sub.6 is alkyl or ##STR4## in the presence of a catalytic amount of a cuprous or cupric salt. The compounds of formula I are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.

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