Process for the preparation of intermediates

Details Process for the preparation of intermediates Process for the preparation of intermediates

1991-08-23

1992-03-24

Evans, J. E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568807, C07D30102, C07D30126, C07C 2940, C07C 3350

Patent

active

050990403

ABSTRACT:
A new process for the preparation of 1-chloro-2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-propan-2-ol of the formula ##STR1## and/or 2-(1-chloro-cyclopropyl)-2-(2-chloro-benzyl)-oxirane of the formula ##STR2## comprising a) reacting in a first step, 2-chloro-benzyl chloride of the formula ##STR3## with comminuted magnesium in the presence of a mixture of toluene and tetrahydrofuran, in which the ratio of toluene to tetrahydrofuran is between 65:35 and 95:5 parts by weight, at a temperature between 0.degree. C. and 100.degree. C., the ratio of 2-chloro-benzyl chloride to tetrahydrofuran being such that between 1 and 3 moles of tetrahydrofuran are present per mol of 2-chloro-benzyl chloride, and subsequently separating off any magnesium which may still be present, and

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