Process for the preparation of insulin or an insulin...

Details Process for the preparation of insulin or an insulin... Process for the preparation of insulin or an insulin...

2006-10-02

2010-02-09

Landsman, Robert (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C530S324000, C530S344000

Reexamination Certificate

active

07659363

ABSTRACT:
The present invention comprises a process for preparing insulin or an insulin derivative with correctly linked cysteine bridges from a precursor of said insulin or insulin derivative, wherein said precursor is subjected to a folding process in the presence of cysteine or cysteine hydrochloride and a chaotropic auxiliary compound. The insulin or insulin derivative with correctly linked cysteine bridges is obtained by enzymic cleavage by means of trypsin or a trypsin-like enzyme and, where appropriate, additionally by means of carboxypeptidase B and subsequent purification on an adsorber resin, which process is carried out at varied pH and temperature ranges.

REFERENCES:
patent: 5407810 (1995-04-01), Builder et al.
patent: 6380355 (2002-04-01), Rubroder et al.
patent: 0668292 (1995-08-01), None
patent: WO 01/46453 (2001-06-01), None

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