Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1984-08-01
1987-01-27
Waddell, Frederick E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
C07K 740
Patent
active
046393323
ABSTRACT:
The invention relates to a process for the preparation of insulin derivatives of the formula I ##STR1## in which R.sup.30 represents the radical of a neutral L-amino acid which can be genetically coded, X represents identical or different radicals of L-amino acids which can be genetically coded, at least one of which is a basic amino acid, it being possible for the C-terminal member to be homoserine-lactone, Y denotes Phe or H and n denotes 1, 2 or 3, by splitting of intermediates, proinsulin, preproinsulin or analogs thereof, which comprises carrying out the splitting reaction close to the isoelectric point of the insulin derivatives of the formula I in the presence of an aromatic hydroxy compound.
REFERENCES:
patent: 2920014 (1960-01-01), Petersen et al.
patent: 3884897 (1975-05-01), Geiger et al.
Chemical Abstracts, vol. 79, (1973), 76289c.
Hoechst Aktiengesellschaft
Waddell Frederick E.
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