Process for the preparation of inducers of non-specific immunity

Details Process for the preparation of inducers of non-specific immunity Process for the preparation of inducers of non-specific immunity

1988-10-07

1992-03-10

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

435236, 435238, 435948, A61K 3912, A61K 39275

Patent

active

050948504

ABSTRACT:
Inducers of non-specific immunity are obtained by increasing the pH of a virus suspension of viruses which elicit non-specific immunity and then heating the pH-increased virus suspension. The pH value can be increased to between about 8 and 11 and heating is carried at temperature between about 50.degree.-60.degree. C.

REFERENCES:
patent: 4687664 (1987-08-01), Philapitsch et al.
Mayr, A. et al. 1986, J. Vet. Med. Ser. B 33 321-339.
Mueller-Bruneckert, G. et al. 1986, Comparison of the Effect of Viral Immunity Inducers PIND-AVI and . . . , J. Vet. Med. Ser B 33 185-195.
Breiter, N. et al. 1985, Investigations on the Efficacy of the Paraimmunity Inactivated Avipoxvirus and PIND-ORF, Strahlentherapie 161 168-176.
Mayr, A. et al. 1986, Tierarztl Prax. 14 237-244.
Erfle, V. et al. 1983, Zentrabl Veterinaermed Reihe B 30 36-47.
Rubin, D. 1981, Immunologic Tolerance After Oral Administration of Reovirus: J. Immunol. 127: 1697-701.
Biological Abstracts, vol. 71, 1981, para. No. 52535, Philadelphia, PA, U.S.; P. Thein et al.: "Experiences with Using a Paramuniring Inducer PIND-AVI in Equine Practice", & Zentralbl Veterinaermed Reihe B 27(6): 499-512, 1980.
Biological Abstracts, vol. 73, 1982, Para. No. 75911, Philadelphia, PA, U.S.: P. Thein et al.: "Comparative Studies on the Activity of Paraimmunity Inducer Phytohemagglutinin PMITOGEN and Rhinopneumonites Virus on the Peripheral Leukocytes of the Horse", & Zentralbl Veterinaermed Reithe B 28(6): 432-449, 1981.

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