Process for the preparation of indoles from anilines and ethanol

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D20902

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043762050

ABSTRACT:
A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with an ethanolamine in the vapor phase, the liquid phase or a mixed vapor-liquid phase. Various solid acids, metals and activated carbon can be used as catalysts for this reaction. The present invention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive compounds as the starting materials.

REFERENCES:
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patent: 3984434 (1976-10-01), O'Murchu
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Ind. Eng. Chem., Prod. Res. Dev., vol. 15, No. 3, 1976, Bhattacharyya and Nandi, "Synthesis of N-N-Dimethylaniline from Aniline and Methanol", pp. 201-206.
Chemical Abstracts, 66, 75974s, (1967), pp. 7126-7127.
Chemical Abstracts, 70, 78437n, (1969), p. 6.
Ind. Eng. Chem. 43(7), 1579, (1951), Catalytic Reactions of Aromatic Amines, Alkylation with Alcohols, Hill et al.
Chemical Abstracts, 82, P170329z, (1975), Governale et al.
J.A.C.S., 101:2, Jan. 17, 1979, Reactions of Aniline with Olefins Catalyzed by Group 8 Metal Complexes: N-Alkylation and Heterocycle Formation.
"Classification of Catalysts by Reactions", edited by Tarama Laboratory Staff of Kyoto University, Japan, published by Kagaku Kogyo Sha (Chemical Industrial Co.) of Tokyo, Japan, pp. 74-76, (Sep. 1, 1971). (With Translation).
Tanabe, "Solid Acids and Bases", Acad. Press, NY, pp. 1-3, (1970).
"Classification of Catalysts by Reactions," Kagaku Kogyo Sha, (Chemical Industrial Co.), pp. 74-76, (Sep. 1, 1971).

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