Process for the preparation of indoles

Details Process for the preparation of indoles Process for the preparation of indoles

1982-05-05

1984-06-26

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20908

Patent

active

044567600

ABSTRACT:
A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with a 1,2-glycol in the liquid phase in the presence of a catalyst containing metallic copper and/or copper oxide. The present ivention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive starting materials.

REFERENCES:
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patent: 3984434 (1976-10-01), O'Murchu
J. A. C. S., Heine et al., "The Synthesis of Some N-Arylethylenimine", 76, 2503, (1954), p. 2503.
Ind. Eng. Chem., Prod. Res. Dev., vol. 15, No. 3, 1976, Bhattacharyya and Nandi, "Synthesis of N-N-Dimethylaniline from Aniline and Methanol", pp. 201-206.
Chemical Abstracts, 66, 75974s, (1967), pp. 7126-7127.
Chemical Abstracts, 70, 78437n, (1969), p. 6.
Ind. Eng. Chem., 43, (7), 1579, (1951), Catalytic Reactions of Aromatic Amines, Alkylation with Alcohols, Hill et al.
Chemical Abstracts, 82, P170329z, (1975), Governale et al.
J. A. C. S., 101:2, Jan. 17,1979, "Reactions of Aniline with Olefins Catalyzed by Group 8 Metal Complexes: N-Alkylation and Heterocycle Formation".
"Classification of Catalysts by Reactions", Edited by Tarama Laboratory Staff of Kyoto University, Japan, published by Kagaku Kogyo Sha, (Chemical Industrial Co.), of Tokyo, Japan, pp. 74-76, (Sep. 1, 1971), (with translation).

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