Process for the preparation of indoles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D20908, C07D20912

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active

044736983

ABSTRACT:
A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with a 1,2-glycol in the vapor phase, the liquid phase or a mixed vapor-liquid phase. A salt of a metal of group IIa of the periodic table, a salt of iron, a salt of cobalt and/or a salt of nickel are used as the catalyst for this reaction. The present invention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive compounds as the starting materials.

REFERENCES:
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patent: 3984434 (1976-10-01), O'Murchu
Zovata et al., vol. 67, Chemical Abstracts 21278V, (1967).
J.A.C.S., 101:2, Jan. 17, 1979, "Reactions of Aniline with Olefins Catalyzed by Group 8 Metal Complexes: N-Alkylation and Heterocycle Formation".
"Classification of Catalysts by Reactions", Kagaku Kogyo Sha, (Chemical Industrial Co.), pp. 74-76, (Sep. 1, 1971).
J.A.C.S., Heine et al., "The Synthesis of Some N-Arylethylchimin 76, 2503, (1954), p. 2503.
Ind. Eng. Chem., Prod. Res. Dev., vol. 15, No. 3, 1976, Bhattacharyya and Nandi, "Synthesis of N,N-Dimethylaniline from Aniline and Methanol", pp. 201-206.
Chemical Abstracts, 66, 75974s, (1967), Kosolapoff, pp. 7126-7127.
Chemical Abstracts, 70, 78437n, (1969), Yamaguchi, p. 6.
Ind. Eng. Chem. 43(7), 1579, (1951), Catalytic Reactions of Aromatic Amines, Alkylation with Alcohols, Hill et al.
Chemical Abstracts, 82, P170329z, (1975), Governale et al.

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