Process for the preparation of indoles

Details Process for the preparation of indoles Process for the preparation of indoles

1981-05-18

1984-03-13

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20908, C07D20912

Patent

active

044369166

ABSTRACT:
A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with a 1,2-glycol in the vapor phase, the liquid phase or a mixed vapor-liquid phase. A sulfide or selenide or cadmium and/or zinc are used as the catalyst for this reaction. The present invention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive compounds as the starting materials.

REFERENCES:
patent: 3699120 (1972-10-01), Bakke et al.
patent: 3984434 (1976-10-01), O'Murchu
J.A.C.S., Heine et al., "The Synthesis of Some N-Arylethylenimines" 76, 2503, (1954) p. 2503.
Ind. Eng. Chem., Prod. Res. Dev., vol. 15, No. 3, 1976, Bhattacharyya and Nandi, "Synthesis of N-N-Dimethylaniline from Aniline and Methanol", pp. 201-206.
Chemical Abstracts, 66, 75974s, (1967), pp. 7126-7127.
Chemical Abstracts, 70, 78437n, (1969), p. 6.
Ind. Eng. Chem. 43(7), 1579, (1951), Catalytic Reactions of Aromatic Amines, Alkylation with Alcohols, Hill et al.
Chemical Abstracts, 82, P170329z, (1975), Governale et al.
J.A.C.S., 101:2, Jan. 17, 1979, "Reactions of Aniline with Olefins Catalyzed by Group 8 Metal Complexes: N-Alkylation and Heterocycle Formation".
"Classification of Catalysts by Reactions", edited by Tarama Laboratory Staff of Kyoto University, Japan, published by Kagaku Kogyo Sha (Chemical Industrial Co.) of Tokyo Japan, pp. 74-76, (Sep. 1, 1971).

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