Process for the preparation of indole and skatole

Details Process for the preparation of indole and skatole Process for the preparation of indole and skatole

1982-05-11

1984-09-25

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20908

Patent

active

044736991

ABSTRACT:
Indole, and/or methyl-substituted indoles are described as prepared from the corresponding 2-(cyanomethyl)cyclohexanone starting material through a catalytic reaction in the presence of hydrogen, using a metal, or metal compound, of Group VIII or Group Ib of the Periodic Table. The reaction is carried out at an elevated temperature at high conversion to yield the corresponding indole and (in some cases) tetra- or hexahydroindoles.

REFERENCES:
patent: 3007931 (1961-11-01), Simpson et al.
patent: 3950438 (1976-04-01), Schaafsma et al.
Journal of Organic Chemistry 28, 3442, (1963).
Preparation of Catalysts II, pp. 265-274, van den Berg et al.
Fenaroli's Handbook of Flavor Ingredients, vol. II, Second Ed., CRD Press, (1975).
Journal of Organic Chemistry 27 3882-3885, 1962.
Chemische Berichte 95, pp. 307-318, 1962.

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