Process for the preparation of imidazopyridines

Details Process for the preparation of imidazopyridines Process for the preparation of imidazopyridines

1993-08-04

1994-06-14

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546308, C07D21375, C07D47104

Patent

active

053211375

ABSTRACT:
The invention relates to a novel process for the preparation of imidazopyridines of formula I: ##STR1## in which R is an alkyl having 1-6 C atoms, characterized in that 3,4-diamino-2-chloropyridine (II) is reacted with an acid anhydride of the formula RCO--O--COR 40 (III), in which R is as defined and R' is R or can be another aliphatic or aromatic radical, to give a 4-amino-2-chloro-3-R-CO-aminopyridine (IV), this is converted with 4'-bromomethyl-2-cyanobiphenyl (V), in the presence of an alkali metal alcoholate in an inert solvent, to a 4-amino-2-chloro-3-R-CO-[N-(2'-cyano-biphenyl-4-ylmethyl)-amino]pyridine (VI) and this is treated with a strong acid, a 2-R-4-chloro-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-imidazo[4,5-c]pyridine (VII) being formed as an intermediate.

REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
Stetsenko et al., Ukrainskii Khimicheskii Zhurmal, vol. 39 (7), pp. 703-707 (1973) (Eng. Translation).

Affiliated with

Also associated with

Rating

Process for the preparation of imidazopyridines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of imidazopyridines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of imidazopyridines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1250271