Process for the preparation of imidazole compounds

Details Process for the preparation of imidazole compounds Process for the preparation of imidazole compounds

2005-01-18

2005-01-18

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S155000, C546S157000, C546S158000

Reexamination Certificate

active

06844439

ABSTRACT:
A process for the preparation of 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone which comprises reacting 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone with a C6-8alkyllithium compound, 1-methylimidazole and a tri(C4-6alkyl)silyl halide to obtain better yields of the above product.

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Shapiro, et al., “Synthesis of 2,5-Dilithio-1-Methylimidazole,”Tetrahedron Letters, 1993, 3401-3404, vol. 34, No. 21.
Shapiro, et al., “Carboxylate Protection for the Synthesis of 4,5-Disubstituted 1-Methylimidazoles,”J. Org. Chem., 1994, 5524-5526, vol. 59.

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