Process for the preparation of ibuprofen

Details Process for the preparation of ibuprofen Process for the preparation of ibuprofen

1999-03-31

2000-07-25

Woodward, Michael P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5110

Patent

active

060938471

ABSTRACT:
The present invention relates to an process for the preparation of ibuprofen, which comprises reacting para isobutyl phenylethanol (p-IBPE), a halide source, a protonic acid, water and the catalyst which is a compound having formula 1 which is shown herebelow: ##STR1## Wherein M = a group VIII metal specifically palladium or platinum,

REFERENCES:
patent: 4843172 (1989-06-01), Tanaka et al.
patent: 5055611 (1991-10-01), Lin et al.
patent: 5166418 (1992-11-01), Hendricks et al.
patent: 5278335 (1994-01-01), Chockaingam

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