Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1988-06-28
1992-04-28
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435141, 435196, 435280, 4352521, 4352525, 435823, 435882, C12P 700, C12N 900
Patent
active
051089173
ABSTRACT:
A process is provided for the preparation of ibuprofen enriched in R isomer, which comprises subjecting an ester of ibuprofen, to the action of a micro-organism or substances derived thereof, that will stereoselectively hydrolyse the ester to form ibuprofen predominantly having R configuration.
REFERENCES:
patent: 4886750 (1989-12-01), Bertola et al.
"Asymmetric Hydrolysis of (.+-.)-alpha-substituted Carboxylic Acid Esters with Microorganism," Agricultural and Biological Chemistry, vol. 45, No. 6, (1981) pp. 1389-1392.
Bergey's Manual of Systematic Bacteriology, vols. 1 & 2, ed. Krieg, pp. 269-271 (vol. 1), pp. 1015-1019 and 1131 (vol. 2).
Bertola Mauro A.
De Smet Marie J.
Marx Arthur F.
Phillips Gareth T.
Brown Johnnie R.
Gist-Brocades N.V.
Shell Internationale Research Maatschappij B.V.
Webber Pamela S.
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