Process for the preparation of hydroxyphosphinylureidobenzylpeni

Details Process for the preparation of hydroxyphosphinylureidobenzylpeni Process for the preparation of hydroxyphosphinylureidobenzylpeni

1978-05-22

1979-12-04

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49968

Patent

active

041771893

ABSTRACT:
An improved process for the preparation in high yields of a compound of the formula ##STR1## wherein R is an optionally substituted phenyl group, Y is selected from the group consisting of Me and a hydrocarbon, Me is a metal cation and E is selected from the group consisting of hydrogen and a metal cation comprising reacting a compound of the formula ##STR2## wherein Q is selected from the group consisting of hydrogen and a silyl protecting group, Rz is an optionally substituted phenyl with the proviso that any hydroxy group present on the phenyl are replaced by --OQz, wherein Qz is a silyl protecting group and Ez is a carboxyl protecting group, with a compound of the formula ##STR3## wherein Z is a halogen and X is selected from the group consisting of OY and Z at low temperatures under anhydrous conditions and carefully hydrolyzing the resulting product either with just enough water to remove protecting groups and hydrolyze the Z groups to hydroxy groups and, still under anhydrous conditions, reacting the compound obtained with an organic metal salt carrying a metal cation Me or, in the case wherein the organic solvent is water-insoluble, with an excess of water, followed by washing the mixture with water acidified to a pH of 0 to 3, extracting the organic phase with neutral water and forming a salt with a hydroxide or a salt carrying a salt-forming cation Me.

REFERENCES:
patent: 3945994 (1976-03-01), Bruynes et al.
patent: 4067986 (1978-01-01), Bruynes et al.

Affiliated with

Also associated with

Rating

Process for the preparation of hydroxyphosphinylureidobenzylpeni does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of hydroxyphosphinylureidobenzylpeni, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of hydroxyphosphinylureidobenzylpeni will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-91100