Process for the preparation of hydroxy acids

Details Process for the preparation of hydroxy acids Process for the preparation of hydroxy acids

1989-06-02

1992-03-24

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435146, C12P 742

Patent

active

050988417

ABSTRACT:
The invention relates to a preferably continuous process for the preparation of R- or S-2-hydroxy-4-phenylbutyric acid in very high enantiomeric purity, which comprises reducing 2-oxo-4-phenylbutyric acid with the enzyme D-lactate dehydrogenase from Staphylococcus epidermidis or with the enzyme L-lactate dehydrogenase from bovine heart, respectively, in the presence of NAD(H) and formate or ethanol and formate dehydrogenase or alcohol dehydrogenase, respectively. R-2-hydroxy-4-phenylbutyric acid is a valuable intermediate in the preparation of ACE inhibitors or their precursors.

REFERENCES:
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Gunther et al., Jour. of Biotech., vol. 5, pp. 53-65 (1987).
Yamazaki et al., Agric. Biol. Chem., vol. 50, No. 10, pp. 2621-2631 (1986).
Yamazaki et al., Agricol. Biol. Chem., vol. 50, No. 12, pp. 3213-3214 (1986).

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