Process for the preparation of human or the derivatives thereof

Details Process for the preparation of human or the derivatives thereof Process for the preparation of human or the derivatives thereof

1984-08-15

1986-07-22

Waddell, Frederick E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C07K 740

Patent

active

046018522

ABSTRACT:
What is disclosed is a method for making human insulin or modified human insulin from pig insulin or modified pig insulin by reacting the pig insulin starting material at a pH below its isoelectric point with an excess of a threonine ester in the presence of trypsin or a trypsin-like enzyme.

REFERENCES:
patent: 3276961 (1966-10-01), Bodanszky et al.
patent: 3903068 (1975-09-01), Ruttenberg
patent: 4029642 (1977-06-01), Obermeier
Morihara et al., Nature 280, 412, 413 (1979).
Morihara et al., Chem. Abstr. 92, 142752 (1980).
Morihara et al., Biochem. Biophys. Res. Comm. 92, 396-402 (1980).
Chem. Abstr., 9th Collective Index, vols. 76-85 (1972-1976), p. 5608 GS.
Hennrich, Kontakte 1/73, pp. 8-11, E. Merck, Darmstadt, (1973).
Hennrich, Kontakte 2/73, pp. 3-8, E. Merck, Darmstadt, (1973).
Young et al., J. Biol. Chem. 236, 743-748 (1961).
Jonczyk et al., Z. Physiol. Chemie 362, 1591-1598 (1981).
Rose et al., "Rapid Preparation of Human Insulin and Insulin Analogues in High Yield by Enzyme-Assisted Semi-Synthesis", Biochem. J., (1983) 211, 671-676.
Jonczyk et al., "Eine neue Semisynthese des Humaninsulins Tryptisch-Katalysierte Transpeptidierung von Schweineinsulin mit L-Threonon-tert-butylester", Z. Physical. Chem., 362, 1591-1598 (1981).
"Basic Principles of Organic Chemistry", Roberts et al., W. A. Benjamin, Inc., New York, 1965, pp. 715-716.
"Biochemistry", Lehninger, Worth Publishers, Inc., New York, 1970, pp. 158-159.
Fruton, "Proteinase-Catalyzed Synthesis of Peptide Bonds", Advances in Enzymology 53, 239-306, Ed. A. Mesiter, J. Wily & Sons (1982), pp. 256-258.

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