Process for the preparation of human factor VIII and analogs of

Details Process for the preparation of human factor VIII and analogs of Process for the preparation of human factor VIII and analogs of

1992-11-03

1995-06-06

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4352403, 935 34, C12N 506, C12N 510, C12N 950

Patent

active

054222508

ABSTRACT:
The present invention relates to a process for the preparation of factor VIII or an analog of factor VIII by culture, in a Culture medium, of cells which produce said factor VIII or analog of factor VIII and the separation of factor VIII or its analog, wherein the culture medium contains at least one derivative of a polycationic and/or polyanionic polymer.
It also relates to factor VIII or analog of factor VIII and to the complex of factor VIII or analog of factor VIII with a derivative of a polycationic and/or polyanionic polymer obtained by using this process.

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