Process for the preparation of HMG-CoA reductase inhibitors and

Details Process for the preparation of HMG-CoA reductase inhibitors and Process for the preparation of HMG-CoA reductase inhibitors and

1985-01-31

1986-09-09

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564129, 564158, 558405, 556416, 549419, C07D30930, C07C10208, C07C10200, C07C103167, C07C103173

Patent

active

046110674

ABSTRACT:
This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl 4-cyano-3(R)-hydroxybutanoate as a chiral synthon for the stereospecific introduction of the 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety.

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