Process for the preparation of HMG-CoA reductase inhibitors

Details Process for the preparation of HMG-CoA reductase inhibitors Process for the preparation of HMG-CoA reductase inhibitors

1985-01-31

1986-04-15

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 53, 560 56, 560 59, 560 55, C07D30930, C07C 69738, C07C 69732, C07C 69716, C07C 69675

Patent

active

045829144

ABSTRACT:
This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl 4-halo-3(S)-hydroxybutanoate as a chiral synthon for the stereospecific introduction of the 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety.

Affiliated with

Also associated with

Rating

Process for the preparation of HMG-CoA reductase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of HMG-CoA reductase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of HMG-CoA reductase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1439662