Process for the preparation of highly monodispersed polymeric hy

Details Process for the preparation of highly monodispersed polymeric hy Process for the preparation of highly monodispersed polymeric hy

1997-01-07

1999-02-23

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, 528481, 528482, 528488, A61K 951, A61K 4732, B01J 1320

Patent

active

058741119

ABSTRACT:
Preparation of highly monodispersed polymeric hydrophilic nanoparticles having a size of up to 100 nm (in which may have drug substances encapsulated therein. The process comprises subjecting a mixture of an aqueous solution of a monomer or preformed polymer reverse micelles, a cross linking agent, initiator, and optionally, a drug or target substance to polymerization. The polymerized reaction product is dried for removal of solvent to obtain dried nanoparticles and surfactant employed in the process of preparing reverse micelles. The dry mass is dispersed in aqueous buffer and the surfactant and other toxic material are removed therefrom.

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patent: 4741872 (1988-05-01), De Luca et al.
patent: 4871716 (1989-10-01), Longo et al.
patent: 5183879 (1993-02-01), Yuash et al.
patent: 5508313 (1996-04-01), Delgado et al.

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