Process for the preparation of high purity methotrexate and deri

Details Process for the preparation of high purity methotrexate and deri Process for the preparation of high purity methotrexate and deri

1980-08-14

1983-02-22

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

C07D47508

Patent

active

043749879

ABSTRACT:
An improved process for the preparation and purification of N-{p-([2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as methotrexate, using the alkali metal, calcium and zinc salts of N-methyl-p-aminobenzoylglutamate, tetraaminopyrimidine sulfate, 1,1,3-tribromoacetone and the alkali metal and zinc salts of methotrexate.

REFERENCES:
patent: 2570391 (1951-10-01), Seeger

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