Process for the preparation of halo-4-phenoxyquinolines

Details Process for the preparation of halo-4-phenoxyquinolines Process for the preparation of halo-4-phenoxyquinolines

1998-01-15

1999-10-26

Mach, D. Margaret M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21516

Patent

active

059731532

ABSTRACT:
The present invention relates to a new improved, simplified process for the preparation of halo-4-phenoxyquinolines, whereby thionyl chloride is used as the chlorinating agent to prepare the corresponding chloroquinoline intermediate prior to the final coupling reaction, and a single, inert high boiling polyether solvent is used throughout the entire reaction procedure.

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