Process for the preparation of glyoxal-2-oximes

Details Process for the preparation of glyoxal-2-oximes Process for the preparation of glyoxal-2-oximes

1979-08-20

1980-09-23

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424272, C07D26114, A61K 3142

Patent

active

042244501

ABSTRACT:
Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.

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