Process for the preparation of glycine-conjugated bile acids

Details Process for the preparation of glycine-conjugated bile acids Process for the preparation of glycine-conjugated bile acids

1995-06-06

1997-04-01

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C07J 900, C07J 4100

Patent

active

056167415

ABSTRACT:
A process for the preparation of glycine-conjugated bile acids as general formula (I):

REFERENCES:
A.M. Bellini et al., "Antimicrobial activity of cholane compounds Cholic and deoxycholic acids derivatives (Part I)", Eur. J. Med. Chem.--Chim. Ther., vol. 18, 1983, No. 2, pp. 185-190.
J. Goto et al., "Studies on Analysis of Bile Acids. Preparation of 3-Glucuronides of 7-and 12-Oxo Bile Acids", Chem. Pharm. Bull. vol. 3, (1982), pp. 4422-4428
A.F. Hofmann et al., "The biological utility of bile acid conjugation with glycine or taurine", Falk Symposium 40, Advances in Glucuronide Conjugation, pp. 245-264 (1984).
Enciclopedia Della Chimica, vol. II, pp. 420-425, Uses, Edizioni Scientifiche, Florence, 1972.
H. Igimi et al. `Cholesterol gallstone dissolution in bile: dissolution kinetics of crystalline (anhydrate and monohydrate) cholesterol with chenodeoxycholate, ursodeoxycholate and their glycine and taurine conjugates.`, J. Lipid Res., vol. 22, No. 2, 1981, pp. 254-270.
R. Raedsch et al. `Kinetics of cholesterol gallstone dissolution by glycocheno-, glycoursodeoxycholic acid, end mixtures thereof in vitro.`, Z. Gastroenterologie, vol. 19, No. 4, 1981, pp. 159-163.

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