Process for the preparation of gestodene

Details Process for the preparation of gestodene Process for the preparation of gestodene

1995-08-16

1998-02-17

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C07J 500

Patent

active

057193002

ABSTRACT:
Disclosed is a process for the preparation of Gestodene (formula I) from (-)estra-1,3,5(10),8-tetraen-3-methoxy-18-methyl-17.beta.-hydroxy. ##STR1##

REFERENCES:
patent: 3876670 (1975-04-01), Coombs et al.
patent: 4081537 (1978-03-01), Hofmeister et al.
patent: 4719054 (1988-01-01), Hofmeister et al.
patent: 4923640 (1990-05-01), Bohlmann et al.
Chen et al., "Synthesis of 17alpha-ethynyl-17beta-hydroxy-18-methylestra-delta 4,15-dien-3-one (gestodene)." Reproduction and Contraception, 15(3): 197-201, 1995.
Hofmeister, et al., "Syntheses of gestodene". Arzneimittel-Forschung/Drug Research, 36(1): 781-783, 1986.
Tetrahedron Letters, Nakamara et al. "Highly Stereoselective Formation of Enol Silyl Ethers" No. 24, 2079-2082 (Jun. 1978).
JACS, Nakamura et al. "Quaternary Ammonium Enolates As Synthetic Intermediate", vol. 98, No. 8, 2346-2348 (1976).

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