Process for the preparation of Fluvastatin Sodium salt

Details Process for the preparation of Fluvastatin Sodium salt Process for the preparation of Fluvastatin Sodium salt

2007-04-19

2010-02-16

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

07662848

ABSTRACT:
The present invention is directed to a process for preparing Fluvastatin Sodium salt by basic hydrolysis of its alkyl ester. The reaction is performed in conditions suitable to allow a selective hydrolysis of the desired syn isomer, while the unwanted anti isomer is removed by extraction, thus reducing its content in the final product; this diastereomer is the main impurity of Fluvastatin sodium salt and its ester precursor.

REFERENCES:
patent: 4739073 (1988-04-01), Kathawala
patent: 2005/0159615 (2005-07-01), Lifshitz-Liron et al.
patent: 0 363 934 (1990-04-01), None
patent: WO 01/92223 (2001-12-01), None
patent: WO 2004/113292 (2004-12-01), None

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