Process for the preparation of fluoromethylpyridines

Details Process for the preparation of fluoromethylpyridines Process for the preparation of fluoromethylpyridines

1986-05-09

1988-05-17

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546346, C07D21361

Patent

active

047451939

ABSTRACT:
Fluoromethylpyridines of the formula: ##STR1## wherein the group F.sub.n H.sub.3-n C-- may be ortho, meta or para to the ring nitrogen atom, n is 1, 2 or 3, m is 1 to 4, X is Cl, Br, I or F and, when m is 2, 3 or 4 the substituents represented by X may be the same or different, at least one X being ortho or para to the F.sub.n H.sub.3-n C-- group, are prepared by reacting a compound of the formula: ##STR2## wherein Y is Cl, Br, I or F and m is 1 to 4, with potassium fluoride in a polar aprotic solvent under substantially anhydrous conditions. These fluoromethylpyridines are useful as intermediates for herbicides. 3,4,5-trifluoro-2-trifluoromethylpyridine and 2,6-difluoro-3-difluoromethylpyridine are novel compunds.

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