Process for the preparation of faropenem

Details Process for the preparation of faropenem Process for the preparation of faropenem

2011-07-12

2011-07-12

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07977475

ABSTRACT:
The present invention is related to processes for the preparation of faropenem, which comprises treating the compound of Formula II,with an alkali metal salt of a substituted or unsubstituted C5-10carboxylic acid and a catalytic amount of a palladium complex in the presence of an organic solvent, followed by the treatment of the reaction mixture of with water and a water miscible solvent, and isolating a hydrate of an alkali metal salt of faropenem from the reaction mass, wherein water is not removed from the reaction mixture in water treatment or isolation steps.

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patent: 5885981 (1999-03-01), Iwata et al.
patent: 7358356 (2008-04-01), Takase et al.
patent: 2009/0275746 (2009-11-01), Parthasaradhi Reddy et al.
patent: 0 199 446 (1986-10-01), None
patent: 0 410 727 (1991-01-01), None
patent: 4-41489 (1992-02-01), None
patent: 04041489 (1992-02-01), None
T. Nakatsuka and A. Kaneko, Research on the Process of Synthesis of Sodium Salt of Faropenem an Antibiotic of Faropenem, Farumashia (Japanese). (2002) 38(3), pp. 219-223 (and translation).
Han, Chinese Journal of Pharmaceuticals, 339-341 2001.
Translation of Han 2001.
Translation of JP 04041489A.
second translation of JP04041489 (1992).

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