Process for the preparation of factor VIII:C-deficient plasma, a

Details Process for the preparation of factor VIII:C-deficient plasma, a Process for the preparation of factor VIII:C-deficient plasma, a

1988-03-04

1991-06-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

530383, A61K 3516

Patent

active

050212435

ABSTRACT:
A process for the preparation of a factor VIII:C-deficient plasma is made available, in which a starting plasma is consecutively treated with antibodies against von Willebrand factor and antibodies against factor VIII:Ag. The deficient plasma prepared in this way contains less than 0.5% residual activity of factor VIII:C.

REFERENCES:
patent: 4716117 (1987-12-01), Kuo et al.
Hornsey et al. "Artificial Factor VIII Deficient Plasma" J. Clin Pathol 1988; 41:562-567.
Fass et al. "Monocolonal Antibodies to Porcine Factor VIII Coagulant . . . " Blood, vol. 59, No. 3 (Mar.) 1982:594-600.
Takase et al. "Production of Factor VIII Deficient Plasma . . . " Brit J. Haematology 1987:66, 497-502.
Tran et al. "Preparation of Factor VIII-Free Plasma . . . " Haemostasis 13:73-77 (1983).
Exner et al. "Factor VIII Deficient Plasma . . . ", Haemostasis 6: 157-162 (1977).
Furlan et al. "Preparation of Factor VIII-Deficent Plasma by Immunoadsorption" Vox Sang 36:342-346 (1979).
Barrowcliffe et al., "Proposed 2nd International Standard for Factor VIII and Von Willebrand Factor Activities in Plasma," Work Health Organization, Expert Committee on Biological Standardization, Geneva Oct., 11-19, 1988.

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