Process for the preparation of ethyltrifluoroacetoacetate

Details Process for the preparation of ethyltrifluoroacetoacetate Process for the preparation of ethyltrifluoroacetoacetate

1986-06-12

1989-11-28

Garner, Vivian

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560183, 562609, 568876, C07C 67313, C07C 69716, C07C 67343

Patent

active

048839043

ABSTRACT:
A process for the preparation of ethyltrifluoroacetoacetate is provided. In this first step, ethyltrifluoroacetate is condensed with ethyl acetate in the presence of sodium ethoxide in cyclohexane. In a second step, the condensation product is neutralized with a protonic acid, such as formic acid, to release an enol. In the third step, the ethyltrifluoroacetoacetate obtained is separated by distillation. The ethyltrifluoroacetoacetate is used as an intermediate in syntheses in the pharmaceutical or plant protection industry.

REFERENCES:
Filler, R. et al., Tetrahedron, 1963, vol. 19, pp. 879-889, Pergamon Press Ltd. (Northern Ireland).
Bergmann, E. D. et al., J. Chem. Soc., (London), 1959, 3278-3285.

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