Process for the preparation of esters of leukotriene A

Details Process for the preparation of esters of leukotriene A Process for the preparation of esters of leukotriene A

1981-12-22

1983-06-07

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549548, C07D30342

Patent

active

043872395

ABSTRACT:
Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A. 9-oxo-5,6-trans-epoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.

REFERENCES:
Corey et al., Tetrahedron Letters, vol. 21, pp. 3463-3466, 4243-4246, (1980).
Baker et al., Tetrahedron Letters, vol. 21, pp. 4123-4126, (1980).
Hammarstrom et al., Biochem. Biophys. Res. Commun., vol. 92 (3), Feb. 12, 1980, pp. 946-953.
Corey et al., Jour. Am. Chem. Soc., vol. 102(4), Feb. 13, 1980, pp. 1436-1439.

Affiliated with

Also associated with

Rating

Process for the preparation of esters of leukotriene A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of esters of leukotriene A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of esters of leukotriene A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2344075