Process for the preparation of epidermal growth factor and new d

Details Process for the preparation of epidermal growth factor and new d Process for the preparation of epidermal growth factor and new d

1973-11-27

1976-04-06

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424 95, C07G 700

Patent

active

039488756

ABSTRACT:
A new procedure has been devised for the preparation of pure epidermal growth factor (EGF) in high yield which involves passing homogenates of submaxillary glands of adult male mice through a polyacrylamide gel column of a low acid pH. Preferably a two step procedure is used wherein the fraction obtained from the polyacrylamide gel chromatography is subjected to DEAE-cellulose chromatography.
The new procedure also provides a new derivative of EGF, lacking the COOH-terminal Leu-Arg residues.

REFERENCES:
chem. Abstracts, Vol. 61, 1964, 8695d, Cohen.
J. of Biol. Chemistry, Vol. 247, Dec. 1972, Savage et al., pp. 7612-7621.
J. of Biol. Chem., Vol. 237, 1962, pp. 1555-1562, Cohen.
J. of Biol. Chem., Vol. 247, Dec. 1972, Savage et al., pp. 7609-7611.
Chem. Abstracts, Vol. 62, 1965, 9381b-9381c, Salvi et al.
J. of Biol. Chemistry, Vol. 247, Sept. 25, 1972, Taylor et al.

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