Process for the preparation of encainide

Details Process for the preparation of encainide Process for the preparation of encainide

1986-02-25

1987-06-23

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546234, C07D21134, C07D21102

Patent

active

046754091

ABSTRACT:
A new and novel process for the preparation of encainide (4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]-benzanilide) has been developed. The process utilizes .alpha.-picoline, O-nitrobenzaldehyde, and anisoyl chloride as starting materials.

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patent: 4000143 (1976-12-01), Dykstra et al.
patent: 4064254 (1977-12-01), Dykstra et al.
patent: 4394507 (1983-07-01), Madding
Dykstra et al, J. Med. Chem., vol. 16, No. 9, pp. 1015-1020 (1973).
Byrne, et al., J. Pharmacology and Experimental Therapeutics, vol. 200, No. 1, pp. 147-154 (1977).
Horwitz, Journal of Organic Chemistry, vol. 21, pp. 1039-1041 (1956).
Stanek, et al., Chem. Abstracts, 49, 314h (1955).
Phillips, Journal of Organic Chemistry, vol. 12, pp. 333-341 (1947).

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